Replacement of glycoprotein B gene sequences in herpes simplex virus type 1 strain ANG by corresponding sequences of the strain KOS causes changes of plaque morphology and neuropathogenicity.

@article{Weise1987ReplacementOG,
  title={Replacement of glycoprotein B gene sequences in herpes simplex virus type 1 strain ANG by corresponding sequences of the strain KOS causes changes of plaque morphology and neuropathogenicity.},
  author={Kerstin Weise and Hermann K{\"a}rner and Joseph Charles Glorioso and Claus Hobe Schroeder},
  journal={The Journal of general virology},
  year={1987},
  volume={68 ( Pt 7)},
  pages={1909-19}
}
DNA sequences encoding glycoprotein B (gB) derived from herpes simplex virus type 1 (HSV-1) strain KOS321 were transferred to HSV-1 ANG. In cotransfection experiments the cloned HSV-1 KOS BamHI G fragment served as donor, and genomic DNA of two ANG variants as recipients. One of these variants, HSV-1 ANG path, expresses gC and the other, C18, was a spontaneous gC-negative mutant. Both ANG strains are of the syncytial (syn) phenotype whereas HSV-1 KOS321 is non-syncytial (syn+). Recombinants… CONTINUE READING

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Individual HSV transcripts : characterization of specific genes

E. K. WAGNER
The Herpesviruses • 1985

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