Replacement of conserved or variable sequences of the mosquito-borne dengue virus 3' UTR with homologous sequences from Modoc virus does not change infectivity for mosquitoes.

@article{Tumban2013ReplacementOC,
  title={Replacement of conserved or variable sequences of the mosquito-borne dengue virus 3' UTR with homologous sequences from Modoc virus does not change infectivity for mosquitoes.},
  author={Ebenezer Tumban and Nyree E. Maes and Erin E Schirtzinger and Katherine Irene Young and Christopher T. Hanson and Stephen S Whitehead and Kathryn A. Hanley},
  journal={The Journal of general virology},
  year={2013},
  volume={94 Pt 4},
  pages={
          783-8
        }
}
The genus Flavivirus includes both vector-borne and no known vector (NKV) species, but the molecular determinants of transmission mode are not known. Conserved sequence differences between the two groups occur in 5' and 3' UTRs. To investigate the impact of these differences on transmission, chimeric genomes were generated, in which UTRs, UTRs+capsid, or the upper 3' UTR stem-loop of mosquito-borne dengue virus (DENV) were replaced with homologous regions from NKV Modoc virus (MODV); the… CONTINUE READING

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