Replacement of Natural Cofactors by Selected Hydrogen Peroxide Donors or Organic Peroxides Results in Improved Activity for CYP3A4 and CYP2D6

@article{Chefson2006ReplacementON,
  title={Replacement of Natural Cofactors by Selected Hydrogen Peroxide Donors or Organic Peroxides Results in Improved Activity for CYP3A4 and CYP2D6},
  author={Amandine Chefson and Jin Zhao and K. Auclair},
  journal={ChemBioChem},
  year={2006},
  volume={7}
}
The cytochrome P450 enzymes (P450s or CYPs) form a ubiquitous family of heme proteins able to catalyze the monooxygenation of a wide range of substrates. P450s are of considerable interest in synthetic organic chemistry because of their impressive ability to catalyze the insertion of oxygen into nonactivated C H bonds. This useful reaction in organic chemistry has received much attention over several decades, but still remains a significant challenge. Some metal catalysts have been successfully… Expand
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