Replacement of N-glycosylation sites on the MHC class II E alpha chain. Effect on thymic selection and peripheral T cell activation.

@article{Ishikawa1995ReplacementON,
  title={Replacement of N-glycosylation sites on the MHC class II E alpha chain. Effect on thymic selection and peripheral T cell activation.},
  author={Sho Ishikawa and Czeslawa Kowal and Bernard Cole and Cole Thomson and Betty Diamond},
  journal={Journal of immunology},
  year={1995},
  volume={154 10},
  pages={5023-9}
}
MHC class II molecules play a central role in thymic selection of developing T cells, Ag presentation to immunocompetent CD4+ T cells, and T cell activation by superantigens. We have established transgenic A.CA mice expressing either the wild-type E alpha d molecule (E alpha/E beta), or an E alpha d molecule altered at an N-glycosylation site on the E alpha chain (residue 78, 78E alpha/E beta or residue 118, 118E alpha/E beta) to identify a possible role for carbohydrates in thymic selection… CONTINUE READING