Replacement of Mycobacterium smegmatis dnaA gene by Mycobacterium tuberculosis homolog results in temperature sensitivity.

Abstract

The genetic aspects of DnaA mediated initiation of oriC replication in mycobacteria are largely unknown. To get insights into the replication initiation process in mycobacteria, we characterized Mycobacterium tuberculosis DnaA and its interactions with oriC. We show that the replacement of Mycobacterium smegmatis dnaA with the M. tuberculosis counterpart… (More)
DOI: 10.1016/j.tube.2011.10.023

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