Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes

@article{Woods1986RepetitiveTR,
  title={Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes},
  author={Niall M. Woods and K. S. Roy Cuthbertson and Peter H. Cobbold},
  journal={Nature},
  year={1986},
  volume={319},
  pages={600-602}
}
In the stressed animal, the vasoactive hormones vasopressin and angiotensin-II and the neurotransmitter noradrenaline induce liver cells to release glucose from glycogen. The intracellular signal that links the cell-surface receptors for noradrenaline (α1) and vasoactive peptides to activation of glycogenolysis is known to be a rise in the cytoplasmic concentration of free calcium ions (free Ca)1–3. The receptors for these agonists induce the hydrolysis of phosphatidylinositol 4,5-bisphosphate… CONTINUE READING
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