Repetitive transgenes in C. elegans accumulate heterochromatic marks and are sequestered at the nuclear envelope in a copy-number- and lamin-dependent manner.

@article{Towbin2010RepetitiveTI,
  title={Repetitive transgenes in C. elegans accumulate heterochromatic marks and are sequestered at the nuclear envelope in a copy-number- and lamin-dependent manner.},
  author={Benjamin D. Towbin and Peter Meister and Brietta L. Pike and Susan M. Gasser},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={2010},
  volume={75},
  pages={555-65}
}
Chromatin is nonrandomly distributed in nuclear space, yet the functional significance of this remains unclear. Here, we make use of transgenes carrying developmentally regulated promoters to study subnuclear gene positioning during the development of Caenorhabditis elegans. We found that small transgenes (copy number ≤50) are randomly distributed in early embryonic nuclei, independent of promoter activity. However, in differentiated tissues, these same transgenes occupied specific subnuclear… CONTINUE READING

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