Repetitive paired-pulse TMS at I-wave periodicity markedly increases corticospinal excitability: A new technique for modulating synaptic plasticity

@article{Thickbroom2006RepetitivePT,
  title={Repetitive paired-pulse TMS at I-wave periodicity markedly increases corticospinal excitability: A new technique for modulating synaptic plasticity},
  author={Gary W. Thickbroom and Michelle Byrnes and Dylan J. Edwards and F. Mastaglia},
  journal={Clinical Neurophysiology},
  year={2006},
  volume={117},
  pages={61-66}
}
  • Gary W. Thickbroom, Michelle Byrnes, +1 author F. Mastaglia
  • Published in Clinical Neurophysiology 2006
  • Psychology, Medicine
  • OBJECTIVE We hypothesised that facilitatory I-wave interaction set up by paired-pulse transcranial magnetic stimulation delivered with I-wave periodicity (iTMS) may reinforce trans-synaptic events and provide a means for modulating synaptic plasticity and cortical excitability. Our objective was to determine whether prolonged iTMS can increase corticospinal excitability, and whether this form of stimulation can have lasting aftereffects. METHODS Paired stimuli of equal strength with a 1.5 ms… CONTINUE READING

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