Repetitive organic dust exposure in vitro impairs macrophage differentiation and function.

@article{Poole2008RepetitiveOD,
  title={Repetitive organic dust exposure in vitro impairs macrophage differentiation and function.},
  author={Jill A. Poole and Neil E. Alexis and Conrad Parks and Amy K MacInnes and Martha J Gentry-Nielsen and Paul D Fey and L. Viktor Larsson and Diane Allen-Gipson and Susanna G. Von Essen and Debra J. Romberger},
  journal={The Journal of allergy and clinical immunology},
  year={2008},
  volume={122 2},
  pages={375-82, 382.e1-4}
}
BACKGROUND Organic dust exposure in the agricultural industry results in significant airway disease and lung function decrease. Mononuclear phagocytes are key cells that mediate the inflammatory and innate immune response after dust exposure. OBJECTIVE We sought to investigate the effect of organic dust extract (ODE) from modern swine operations on monocyte-derived macrophage (MDM) phenotype and function. METHODS Peripheral blood monocytes were obtained by means of elutriation methodology… CONTINUE READING