Repetitive hyperthermia attenuates progression of left ventricular hypertrophy and increases telomerase activity in hypertensive rats.

@article{Oyama2012RepetitiveHA,
  title={Repetitive hyperthermia attenuates progression of left ventricular hypertrophy and increases telomerase activity in hypertensive rats.},
  author={Junnichi Oyama and Toyoki Maeda and Makoto Sasaki and Yoshihiro Higuchi and Koichi Node and Naoki Makino},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2012},
  volume={302 10},
  pages={
          H2092-101
        }
}
We investigated the hypothesis that repetitive hyperthermia (RHT) attenuates the progression of cardiac hypertrophy and delays the transition from hypertensive cardiomyopathy to heart failure in Dahl salt-sensitive (DS) hypertensive rats. Six-week-old DS rats were divided into the following five groups: a normal-salt diet (0.4% NaCl) (NS group), a normal-salt diet plus RHT by daily immersion for 10 min in 40°C water (NS+RHT group), a high-salt diet (8% NaCl) (HS group), a high-salt diet (8… 

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References

SHOWING 1-10 OF 39 REFERENCES

Dual ECE/NEP Inhibition on Cardiac and Neurohumoral Function During the Transition From Hypertrophy to Heart Failure in Rats

TLDR
Dual ECE/NEP inhibitor may provide a new strategy for the treatment of human heart failure after the transition from left ventricular hypertrophy to congestive heart failure in hypertensive rats.

Activation of Matrix Metalloproteinases Precedes Left Ventricular Remodeling in Hypertensive Heart Failure Rats: Its Inhibition as a Primary Effect of Angiotensin-Converting Enzyme Inhibitor

TLDR
MMPs are likely to trigger and promoteLV remodeling, and ACE inhibition directly exerts inhibitory effect on MMPs, leading to the prevention of LV remodeling and dysfunction.

Acute hemodynamic improvement by thermal vasodilation in congestive heart failure.

TLDR
Hemodynamics improve after WWB or SB in patients with chronic CHF, and thermal vasodilation can be applied with little risk if appropriately performed and may provide a new nonpharmacological therapy for CHF.

Repeated sauna therapy increases arterial endothelial nitric oxide synthase expression and nitric oxide production in cardiomyopathic hamsters.

  • Y. IkedaS. Biro C. Tei
  • Medicine, Biology
    Circulation journal : official journal of the Japanese Circulation Society
  • 2005
TLDR
Repeated sauna therapy increases eNOS expression and NO production in cardiomyopathic hamsters with heart failure and upregulated aortic eNos protein expression.

Acute Hemodynamic Improvement by Thermal Vasodilation in Congestive Heart Failure

TLDR
To investigate the acute hemodynamic effects of thermal vasodilation in CHF, 34 patients with chronic CHF were studied and Swan-Ganz catheter was inserted via the right jugular vein and blood pressure, ECG, echo-Doppler, expiration gas, and intracardiac pressures were recorded.

Antioxidant therapy attenuates myocardial telomerase activity reduction in superoxide dismutase-deficient mice.

Improving insulin sensitivity via activation of PPAR-gamma increases telomerase activity in the heart of OLETF rats.

TLDR
It is suggested that improving insulin sensitivity via the activation of peroxisom proliferator-activated receptor-gamma may exert regulatory effects on cardiac telomere biology and may have desirable morphological and functional effects on the diabetic heart.

Single Oral Dose of Geranylgeranylacetone Induces Heat-Shock Protein 72 and Renders Protection Against Ischemia/Reperfusion Injury in Rat Heart

TLDR
Oral GGA is cardioprotective against ischemic insult through its induction of HSP72, and electron microscopy findings revealed that the ischemia/reperfusion-induced damage of myocardial cells was prevented in GGA-treated myocytes.

Chronic Hypoxia Increases Endothelial Nitric Oxide Synthase Generation of Nitric Oxide by Increasing Heat Shock Protein 90 Association and Serine Phosphorylation

TLDR
Data indicate that the association of hsp90 with eNOS is important for increasing ·NO production and limiting e NOS-dependent superoxide anion generation, and appears to play a critical role in protecting the myocardium against ischemic injury.