Repetitive fragmentation products of albumin and alpha1-antitrypsin in glomerular diseases associated with nephrotic syndrome.

@article{Candiano2006RepetitiveFP,
  title={Repetitive fragmentation products of albumin and alpha1-antitrypsin in glomerular diseases associated with nephrotic syndrome.},
  author={Giovanni Candiano and Luca Musante and Maurizio Bruschi and Andrea Petretto and Laura Aparecida Christiano Santucci and Piero Del Boccio and Barbara Pavone and Francesco Perfumo and Andrea Urbani and Francesco Scolari and Gian Marco Ghiggeri},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2006},
  volume={17 11},
  pages={
          3139-48
        }
}
Even if nephrotic syndrome is characterized by massive urinary loss of major plasma proteins, a clear structural characterization based on proteomics has never been reported. Urine and plasma of 23 patients with different idiopathic nephrotic syndromes (10 steroid-sensitive minimal-change nephropathy, seven steroid-resistant FSGS, and six membranous glomerulonephritis) were analyzed with two-dimensional electrophoresis in soft gel, Western blot, and matrix-assisted laser desorption/ionization… CONTINUE READING
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Molecular heterogeneity of urinary albumin in glomerulonephritis: comparison of cardiovascular disease with albuminuria.

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