Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study

Abstract

Global genomic hypomethylation is a common epigenetic event in cancer that mostly results from hypomethylation of repetitive DNA elements. Case–control studies have associated blood leukocyte DNA hypomethylation with several cancers. Because samples in case–control studies are collected after disease development, whether DNA hypomethylation is causal or… (More)
DOI: 10.1007/s10552-010-9715-2

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