Repetitive conundrums of centromere structure and function.

  title={Repetitive conundrums of centromere structure and function.},
  author={Evan E. Eichler},
  journal={Human molecular genetics},
  volume={8 2},
In the last few years, a paradox has emerged regarding the relationship of centromere structure and its function. Most centromeric DNAs analyzed to date are composed of a remarkably complex array of repeat structures. In contrast, recent analyses of neocentromeric DNA reveal that repetitive DNA is not a prerequisite for centromere activity. The ubiquity of repetitive sequences among diverse species at sites of primary constriction argues that there is a strong evolutionary link between… CONTINUE READING

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