Repetitive acute intermittent hypoxia increases expression of proteins associated with plasticity in the phrenic motor nucleus.

@article{Satriotomo2012RepetitiveAI,
  title={Repetitive acute intermittent hypoxia increases expression of proteins associated with plasticity in the phrenic motor nucleus.},
  author={Irawan Satriotomo and Erica A. Dale and Jenny M Dahlberg and Gordon S Mitchell},
  journal={Experimental neurology},
  year={2012},
  volume={237 1},
  pages={103-15}
}
Acute intermittent hypoxia (AIH) initiates plasticity in respiratory motor control, including phrenic long term facilitation (pLTF). Since pLTF is enhanced by preconditioning with repetitive exposure to AIH (rAIH), we hypothesized that a rAIH protocol consisting of 3 AIH exposures per week for 10 weeks (3×wAIH; AIH: 10, 5-min episodes of 10.5% O(2); 5-min normoxic intervals) would enhance expression of molecules that play key roles in pLTF within the phrenic motor nucleus. Immunohistochemical… CONTINUE READING
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Respiratory plasticity following intermittent hypoxia: a guide for novel therapeutic approaches to ventilatory control disorders

  • G. S. Mitchell
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