Repetitive N-WASP–Binding Elements of the Enterohemorrhagic Escherichia coli Effector EspFU Synergistically Activate Actin Assembly

@article{Campellone2008RepetitiveNE,
  title={Repetitive N-WASP–Binding Elements of the Enterohemorrhagic Escherichia coli Effector EspFU Synergistically Activate Actin Assembly},
  author={Kenneth G Campellone and Hui-Chun Cheng and Douglas Robbins and Anosha Siripala and Emma J. McGhie and Richard D Hayward and Matthew D Welch and Michael K Rosen and Vassilis Koronakis and John M Leong},
  journal={PLoS Pathogens},
  year={2008},
  volume={4},
  pages={539 - 548}
}
Enterohemorrhagic Escherichia coli (EHEC) generate F-actin-rich adhesion pedestals by delivering effector proteins into mammalian cells. These effectors include the translocated receptor Tir, along with EspF(U), a protein that associates indirectly with Tir and contains multiple peptide repeats that stimulate actin polymerization. In vitro, the EspF(U) repeat region is capable of binding and activating recombinant derivatives of N-WASP, a host actin nucleation-promoting factor. In spite of the… CONTINUE READING

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