Repetitive DNA sequences linked to the sea urchin spec genes contain transcriptional enhancer-like elements.

@article{Gan1990RepetitiveDS,
  title={Repetitive DNA sequences linked to the sea urchin spec genes contain transcriptional enhancer-like elements.},
  author={Lin Gan and Wen-xiang Zhang and William H. Klein},
  journal={Developmental biology},
  year={1990},
  volume={139 1},
  pages={186-96}
}
The 5' flanking DNA of three related Strongylocentrotus purpuratus genes, Spec1, Spec2a, and Spec2c, were analyzed with respect to structure and cis-regulatory activity. The structural features of DNA sequences upstream of the first intron were highly unusual and implicated certain regions as sites of coordinate control for gene expression. By aligning the genes with a common upstream 600-bp repetitive DNA sequence element, termed RSR, it was shown that a conserved DNA block of approximately… CONTINUE READING