Repertoire-based selection into the marginal zone compartment during B cell development

@article{Carey2008RepertoirebasedSI,
  title={Repertoire-based selection into the marginal zone compartment during B cell development},
  author={John B. Carey and Chantelle S. Moffatt-Blue and Lisa C. Watson and Amanda L Gavin and Ann J. Feeney},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={2043 - 2052}
}
Marginal zone (MZ) B cells resemble fetally derived B1 B cells in their innate-like rapid responses to bacterial pathogens, but the basis for this is unknown. We report that the MZ is enriched in "fetal-type" B cell receptors lacking N regions (N(-)). Mixed bone marrow (BM) chimeras, made with adult terminal deoxynucleotidyl transferase (TdT)(+/+) and TdT(-/-) donor cells, demonstrate preferential repertoire-based selection of N(-) B cells into the MZ. Reconstitution of irradiated mice with… CONTINUE READING