Repertoire Development and the Control of Cytotoxic/Effector Function in Human γδ T Cells

@inproceedings{Urban2010RepertoireDA,
  title={Repertoire Development and the Control of Cytotoxic/Effector Function in Human γδ T Cells},
  author={Elizabeth M. Urban and Andrei I. Chapoval and C David Pauza},
  booktitle={Clinical & developmental immunology},
  year={2010}
}
T cells develop into two major populations distinguished by their T cell receptor (TCR) chains. Cells with the alphabeta TCR generally express CD4 or CD8 lineage markers and mostly fall into helper or cytotoxic/effector subsets. Cells expressing the alternate gammadelta TCR in humans generally do not express lineage markers, do not require MHC for antigen presentation, and recognize nonpeptidic antigens. We are interested in the dominant Vgamma2Vdelta2+ T cell subset in human peripheral blood… CONTINUE READING

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Molecular analysis of human γ/δ clones from thymus and peripheral blood

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