Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement

@article{Weiser1996ReperfusionIO,
  title={Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement},
  author={Martin R Weiser and Jon P. Williams and Francis D. Moore and Lester Kobzik and Minga Ma and Herbert B. Hechtman and Michael C Carroll},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={183},
  pages={2343 - 2348}
}
Reperfusion of ischemic tissue induces an acute inflammatory response that can result in necrosis and irreversible cell injury to both local vascular endothelium and parenchyma. To examine the pathogenesis of ischemia/reperfusion injury, we have used mice deficient in complement components C3, C4, or serum immunoglobulin in a hindlimb model of ischemia. We found that mice homozygous deficient in C3 or C4 were equally protected against reperfusion injury based on a significant reduction in… CONTINUE READING
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