Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain.

@article{Ohtsuki1995ReperfusionI5,
  title={Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain.},
  author={Toshiho Ohtsuki and Mishiya Matsumoto and Yutaro Hayashi and Kenjiro Yamamoto and Kouki Kitagawa and Satoshi Ogawa and Satoshi Yamamoto and Takenobu Kamada},
  journal={The American journal of physiology},
  year={1995},
  volume={268 3 Pt 2},
  pages={H1249-57}
}
5-Lipoxygenase (5-LO) converts arachidonic acid, released from membrane phospholipids upon external stimulation, to leukotriene C4 (LTC4), which induces various kinds of cellular and molecular responses. We examined the effects of 5 min of ischemia on brain 5-LO and LTC4 during reperfusion using the gerbil model of transient forebrain ischemia that develops neuronal necrosis selectively in the hippocampus. Neurons exhibited dense 5-LO immunoreactivity; 5-LO was partially redistributed from… CONTINUE READING

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