Reperfusion-induced arrhythmias and free radicals: studies in the rat heart with DMPO.

Abstract

We have shown that the free radical spin trap DMPO (5,5-dimethyl-1-pyrroline-N-oxide) reduces reperfusion-induced arrhythmias in a dose-dependent manner in the isolated perfused rat heart subjected to 10 min regional ischemia and 3 min reperfusion. At its optimal concentration (1,000 mumol/L) DMPO, added to the perfusate 5 min prior to ischemia, reduced (p… (More)

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@article{Hearse1987ReperfusioninducedAA, title={Reperfusion-induced arrhythmias and free radicals: studies in the rat heart with DMPO.}, author={David J. Hearse and {\'A}rp{\'a}d T{\'o}saki}, journal={Journal of cardiovascular pharmacology}, year={1987}, volume={9 6}, pages={641-50} }