Reperfused gut elaborates PAF that chemoattracts and primes neutrophils.

  title={Reperfused gut elaborates PAF that chemoattracts and primes neutrophils.},
  author={Fernando J. Kim and Ernest Eugene Moore and Fredrick Moore and Walter L. Biffl and Benjamin Fontes and Anirban Banerjee},
  journal={The Journal of surgical research},
  volume={58 6},
Our in vivo model of mesenteric ischemia/reperfusion (I/R) has shown that the gut serves as a priming bed for neutrophils (PMN). Activation of phospholipase A2 (PLA2) during ischemia temporally precedes PMN sequestration in the gut and the appearance of primed PMN in the portal circulation. Therefore, we hypothesized that reperfused gut secretes platelet activating factor (PAF) via PLA2 activation that is responsible for increased PMN chemotaxis and priming for superoxide (O2-) generation… CONTINUE READING
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