Repercussions of digoxin, digitoxin and estradiol on the endometrial histomorphometry of oophorectomized mice

@article{Moscovitz2005RepercussionsOD,
  title={Repercussions of digoxin, digitoxin and estradiol on the endometrial histomorphometry of oophorectomized mice},
  author={Thomas Moscovitz and Jos{\'e} Mendes Aldrighi and Paulo Alexandre Abrahanshon and Telma Maria Ten{\'o}rio Zorn and Angela Flavia Logullo and Ot{\'a}vio Celso Eluf Gebara and Giuseppe M C Rosano and Jos{\'e} Ant{\^o}nio Franchini Ramires},
  journal={Gynecological Endocrinology},
  year={2005},
  volume={20},
  pages={213 - 220}
}
The digitalics (digoxin and digitoxin) have an estrogenic action, confirmed by the presence of gynecomastia observed in men who are users of steroids, and it is also confirmed by the increase of vaginal trophism in postmenopausal female users, although little is known about the endometrium. These effects might result from the similarity of the chemical structures between the digitalics and estrogens. This study evaluated 27 female mice. Twenty-four mice were oophorectomized and in three of them… 
3 Citations
Adverse Effects of Digoxin, as Xenoestrogen, on Some Hormonal and Biochemical Patterns of Male Albino Rats
TLDR
Replacing of this drug by others without estrogenic activity, particularly if it is indicated at a high dose or for a long period of time is recommended, as it disrupts the sexual hormonal pattern and biochemical parameters.
SPIRONOLACTONE/DIGOXIN INDUCED GYNECOMASTIA (A COMPARATIVE CASE STUDY)
TLDR
This pathological case study is about a 54-years male patient who received digoxin & spironolactone as a treatment of choice in dilated cardiomyopathy and is suspecting gynecomastia due to spironlactone and digoxin as the pathological cause.

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TLDR
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