Repellent compound with larger protective zone than DEET identified through activity-screening of Ir 40 a neurons , does not require Or function

@inproceedings{Guda2015RepellentCW,
  title={Repellent compound with larger protective zone than DEET identified through activity-screening of Ir 40 a neurons , does not require Or function},
  author={Tom O. Guda and Pinky Kain and Kavita Sharma and Christine Krause Pham and Anandasankar Ray},
  year={2015}
}
The widely used insect repellent DEET has a limited spatial zone of protection, requiring it to be applied over all exposed areas of skin. Identification of insect DEET-sensing neurons expressing a highly conserved Ionotropic receptor, Ir40a, provides an opportunity to identify new structural classes of volatile agonists as potential spatial repellents. By imaging the activity of the Ir40a+ neurons in D. melanogaster expressing the calcium sensitive GCaMP3 protein, we identify a strong agonist… CONTINUE READING

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