Repeated ventral tegmental area amphetamine administration alters dopamine D1 receptor signaling in the nucleus accumbens.

@article{Hu2002RepeatedVT,
  title={Repeated ventral tegmental area amphetamine administration alters dopamine D1 receptor signaling in the nucleus accumbens.},
  author={Xiaohua Tony Hu and Timothy E. Koeltzow and Donald C. Cooper and George R. Robertson and Francis J. White and Paul Vezina},
  journal={Synapse},
  year={2002},
  volume={45 3},
  pages={
          159-70
        }
}
Neuroadaptations of the mesoaccumbens dopamine (DA) system likely underlie the emergence of locomotor sensitization following the repeated intermittent systemic administration of amphetamine (AMPH). In the nucleus accumbens (NAc), such neuroadaptations include enhanced DA overflow in response to a subsequent AMPH challenge as well as increased sensitivity to the inhibitory effects of D1 DA receptor (D1R) activation and an altered profile of D1R-dependent induction of immediate early genes (IEGs… CONTINUE READING
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