Repeated social defeat selectively increases δFosB expression and histone H3 acetylation in the infralimbic medial prefrontal cortex.

@article{Hinwood2011RepeatedSD,
  title={Repeated social defeat selectively increases δFosB expression and histone H3 acetylation in the infralimbic medial prefrontal cortex.},
  author={Madeleine Hinwood and Ross J. Tynan and Trevor A Day and Frederick Rohan Walker},
  journal={Cerebral cortex},
  year={2011},
  volume={21 2},
  pages={262-71}
}
Exposure to social stress has been linked to the development and maintenance of mood-related psychopathology; however, the underlying neurobiological changes remain uncertain. In this study, we examined numbers of δFosB-immunoreactive cells in the forebrains of rats subjected to 12 episodes of social defeat. This was achieved using the social conflict model whereby animals are introduced into the home cage of older males ("residents") trained to attack and defeat all such "intruders… CONTINUE READING

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Collectively , these findings highlight the importance of the infralimbic mPFC in responding to social stress - a finding that provides insight into the possible neurobiological alterations associated with stress - induced psychiatric illness .
Collectively , these findings highlight the importance of the infralimbic mPFC in responding to social stress - a finding that provides insight into the possible neurobiological alterations associated with stress - induced psychiatric illness .
Collectively , these findings highlight the importance of the infralimbic mPFC in responding to social stress - a finding that provides insight into the possible neurobiological alterations associated with stress - induced psychiatric illness .
Collectively , these findings highlight the importance of the infralimbic mPFC in responding to social stress - a finding that provides insight into the possible neurobiological alterations associated with stress - induced psychiatric illness .
Collectively , these findings highlight the importance of the infralimbic mPFC in responding to social stress - a finding that provides insight into the possible neurobiological alterations associated with stress - induced psychiatric illness .
Collectively , these findings highlight the importance of the infralimbic mPFC in responding to social stress - a finding that provides insight into the possible neurobiological alterations associated with stress - induced psychiatric illness .
Collectively , these findings highlight the importance of the infralimbic mPFC in responding to social stress - a finding that provides insight into the possible neurobiological alterations associated with stress - induced psychiatric illness .
Collectively , these findings highlight the importance of the infralimbic mPFC in responding to social stress - a finding that provides insight into the possible neurobiological alterations associated with stress - induced psychiatric illness .
Collectively , these findings highlight the importance of the infralimbic mPFC in responding to social stress - a finding that provides insight into the possible neurobiological alterations associated with stress - induced psychiatric illness .
We found that exposure to repeated episodes of social defeat increased numbers of cells immunoreactive for histone H3 acetylation , but not for histone H3 phosphoacetylation , in the infralimbic mPFC .
We found that exposure to repeated episodes of social defeat increased numbers of cells immunoreactive for histone H3 acetylation , but not for histone H3 phosphoacetylation , in the infralimbic mPFC .
We found that exposure to repeated episodes of social defeat increased numbers of cells immunoreactive for histone H3 acetylation , but not for histone H3 phosphoacetylation , in the infralimbic mPFC .
We found that exposure to repeated episodes of social defeat increased numbers of cells immunoreactive for histone H3 acetylation , but not for histone H3 phosphoacetylation , in the infralimbic mPFC .
Collectively , these findings highlight the importance of the infralimbic mPFC in responding to social stress - a finding that provides insight into the possible neurobiological alterations associated with stress - induced psychiatric illness .
Collectively , these findings highlight the importance of the infralimbic mPFC in responding to social stress - a finding that provides insight into the possible neurobiological alterations associated with stress - induced psychiatric illness .
Collectively , these findings highlight the importance of the infralimbic mPFC in responding to social stress - a finding that provides insight into the possible neurobiological alterations associated with stress - induced psychiatric illness .
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