Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent cytokine secretion.

@article{Powell2009RepeatedSD,
  title={Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent cytokine secretion.},
  author={Nicole D. Powell and Michael T. Bailey and Jacqueline W. Mays and LaTonia M Stiner-Jones and Mark L Hanke and David A. Padgett and John F Sheridan},
  journal={Brain, behavior, and immunity},
  year={2009},
  volume={23 2},
  pages={225-31}
}
Stress hormones significantly impact dendritic cell (DC) activation and function, typically in a suppressive fashion. However, a social stressor termed social disruption (SDR) has been shown to induce an increase in inflammatory responses and a state of glucocorticoid resistance in splenic CD11b+ monocytes. These experiments were designed to determine the effects of SDR on DC activation, Toll-like receptor-induced cytokine secretion, and glucocorticoid sensitivity. Compared to cells obtained… CONTINUE READING