Repeated methacholine challenge produces tolerance in normal but not in asthmatic subjects.

Abstract

Repeated methacholine challenge in normal nonasthmatic subjects (who require higher doses of methacholine than do asthmatic subjects to produce a 20 percent decrease in FEV1) can produce progressively diminishing methacholine responsiveness (or tolerance) with serial challenges. To determine whether tolerance to methacholine occurs in asthmatic subjects as… (More)

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@article{Beckett1992RepeatedMC, title={Repeated methacholine challenge produces tolerance in normal but not in asthmatic subjects.}, author={W. Beckett and Marjorie E Marenberg and P. E. Pace}, journal={Chest}, year={1992}, volume={102 3}, pages={775-9} }