Repeated maternal separation: differences in cocaine-induced behavioral sensitization in adult male and female mice

@article{Kikusui2004RepeatedMS,
  title={Repeated maternal separation: differences in cocaine-induced behavioral sensitization in adult male and female mice},
  author={Takefumi Kikusui and Sara P Faccidomo and Klaus A Miczek},
  journal={Psychopharmacology},
  year={2004},
  volume={178},
  pages={202-210}
}
Repeated maternal separations profoundly alter the adult stress response, the development of the hypothalamic–pituitary–adrenal axis, and prominently, the GABAergic and monoaminergic systems. These neural changes are postulated to influence the vulnerability to drugs of abuse implicating glucocortocoids in the behavioral responses to psychomotor stimulants. To investigate whether repeated brief maternal separation stress increases behavioral sensitization to cocaine in adult male and female… CONTINUE READING
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