Repeated levodopa infusions in fluctuating Parkinson's disease: clinical and pharmacokinetic data.

Abstract

The short-term efficacy of continuous intravenous infusions of levodopa (with oral peripheral decarboxylase inhibitor) in abolishing or reducing "on-off" fluctuations in patients with Parkinson's disease is well established. However, there are suggestions that clinical response may be less good with longer infusions, or infusions on consecutive days. We… (More)

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