Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men
@article{Nieschlag1999RepeatedII, title={Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men}, author={Eberhard Nieschlag and Dorothee B{\"u}chter and Sigrid von Eckardstein and Katrin Abshagen and Manuela Simoni and Hermann M Behre}, journal={Clinical Endocrinology}, year={1999}, volume={51} }
To investigate the suitability of intramuscular testosterone undecanoate (TU) injections for substitution therapy in hypogonadal men.
136 Citations
Androgen substitution with testosterone undecanoate in survivors of bilateral testicular cancer requires individually‐adjusted injection intervals
- Medicine, BiologyBJU international
- 2011
Study Type – Therapy (case series)
Level of Evidence 4
Serum testosterone and bioavailable testosterone correlate with age and body size in hypogonadal men treated with testosterone undecanoate (1000 mg IM – Nebido®)
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- 2008
Objective To investigate the loading regimen for intramuscular (IM) testosterone undecanoate (Nebido®) to determine whether testosterone and bioavailable testosterone levels achieved correlate with…
Intramuscular testosterone undecanoate for the treatment of male hypogonadism–review of recent data
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Intramuscular testosterone undecanoate with or without oral levonorgestrel: a randomized placebo‐controlled feasability study for male contraception
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This study was designed to prove the efficacy of the long‐acting testosterone undecanoate ester (TU) alone or in combination with oral levonorgestrel (LNG) in a phase II clinical trial.
Testosterone replacement therapy
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The aim of testosterone replacement therapy (TRT) is to improve symptoms and signs of testosterone deficiency including decreased libido, erectile dysfunction, depressed mood, anaemia, loss of muscle…
[Androgen replacement therapy for hypogonadal men].
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- 2003
Male hypogonadism is a group of syndromes in clinic andrology characterized by complete or partial androgen deficiency, androgen replacement therapy should be adopted in all patients of primary hypog onadism and patients who do not have the need of having a child.
[Testosterone replacement: application and surveillance].
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Regular clinical and chemical controls of effect, side effects and contraindications are essential along with long-term substitution in male hypogonadism.
Current topics in testosterone replacement of hypogonadal men.
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Treatment Options for a Patient Experiencing Pruritic Rash Associated with Transdermal Testosterone: A Review of the Literature
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A 22‐year‐old man with hypogonadotropic hypogonadism was receiving monthly intramuscular injections of testosterone replacement therapy. The patient refused to self‐administer the injections because…
Treatment of male hypogonadism with testosterone undecanoate injected at extended intervals of 12 weeks: a phase II study.
- Biology, MedicineJournal of andrology
- 2002
Compared with conventional testosterone enanthate or cypionate treatment requiring injection intervals of 2-3 weeks and resulting in supraphysiological serum testosterone levels, injections of TU at intervals of up to 3 months offer an excellent alternative for substitution therapy of male hypogonadism.
References
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The longer half-life and the smaller injection volume make TU in castor oil a strong candidate for further applications in substitution therapy and in trials for male contraception.
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In replacing an endogenous hormone a safe general principle appears to be to mimic, as closely as possible, the normal concentrations of that hormone or its active metabolites. Following this…
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The different testosterone preparations available or under investigation for substitution are outlined, the current status of monitoring testosterone therapy is summarized, and the different risks and benefits are summarized.
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In conclusion, single injections of 600 mg TB in hypogonadal patients show favorable pharmacokinetics and pharmacodynamics and this new long-acting T ester is a promising new agent for substitution therapy of male Hypogonadism and for male contraception.
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