Repeated intermittent stress exacerbates myocardial ischemia-reperfusion injury.

@article{Scheuer1998RepeatedIS,
  title={Repeated intermittent stress exacerbates myocardial ischemia-reperfusion injury.},
  author={Deborah A. Scheuer and Steven W. Mifflin},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={1998},
  volume={274 2},
  pages={R470-R475}
}
Chronic stress in humans has been correlated with increased risk for ischemic heart disease. Thus experiments were conducted to determine if repeated intermittent restraint stress increased infarct size in a rat model of myocardial ischemia-reperfusion injury. Male Sprague-Dawley rats were subjected to no stress (control) or to daily restraint stress for 1-1.5 h for 8-14 days (stress protocol A) or for 2 h daily for 11 or 12 days (stress protocol B). Myocardial ischemia-reperfusion (30-min… CONTINUE READING