Repeated injection of PEGylated solid lipid nanoparticles induces accelerated blood clearance in mice and beagles

Abstract

Surface modification of nanocarriers with amphiphilic polymer polyethylene glycol (PEG), known as PEGylation, is regarded as a major breakthrough in the application of nanocarriers. However, PEGylated nanocarriers (including liposomes and polymeric nanoparticles) induce what is referred to as the "accelerated blood clearance (ABC) phenomenon" upon repeated… (More)
DOI: 10.2147/IJN.S30943

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