Repeated inhibition of cholinesterase by chlorpyrifos in rats: behavioral, neurochemical and pharmacological indices of tolerance.

@article{Bushnell1994RepeatedIO,
  title={Repeated inhibition of cholinesterase by chlorpyrifos in rats: behavioral, neurochemical and pharmacological indices of tolerance.},
  author={Philip J. Bushnell and Kevin L. Kelly and Thomas R. Ward},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={270 1},
  pages={15-25}
}
Previous work from this laboratory showed that daily s.c. injections of the organophosphate diisopropylfluorophosphate caused prolonged inhibition of cholinesterase (ChE) activity in whole blood and brain and downregulation of muscarinic receptors in the central nervous system; these changes were accompanied by progressive, persistent deterioration of working memory and motor function. Further, a single s.c. injection of the organophosphate insecticide chlorpyrifos (O,O',-diethyl O-3,5,6… CONTINUE READING
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