Repeated ingestion of aspartame-sweetened beverage: effect on plasma amino acid concentrations in individuals heterozygous for phenylketonuria.

@article{Stegink1989RepeatedIO,
  title={Repeated ingestion of aspartame-sweetened beverage: effect on plasma amino acid concentrations in individuals heterozygous for phenylketonuria.},
  author={Lewis D. Stegink and L. J. Jr. Filer and George L. Baker and Edward F. Bell and Ekhard E. Ziegler and Marvin C. Brummel and Wilma L. Krause},
  journal={Metabolism: clinical and experimental},
  year={1989},
  volume={38 1},
  pages={
          78-84
        }
}
  • Lewis D. Stegink, L. J. Jr. Filer, +4 authors Wilma L. Krause
  • Published 1989
  • Chemistry, Medicine
  • Metabolism: clinical and experimental
  • It has been suggested that excessive use of aspartame (APM) (N-L-alpha-aspartyl-L-phenylalanine methyl ester) might grossly elevate plasma aspartate and phenylalanine concentrations in individuals heterozygous for phenylketonuria (PKUH). In study 1 six adult PKUH (three males; three females) ingested three successive 12-oz servings of beverage at 2-h intervals. The study was carried out in two parts in a randomized crossover design. In one arm the beverage was not sweetened. In the other the… CONTINUE READING