Repeated induction of nitric oxide synthase and leishmanicidal activity in murine macrophages.

@article{Cunha1993RepeatedIO,
  title={Repeated induction of nitric oxide synthase and leishmanicidal activity in murine macrophages.},
  author={Fernando Queiroz Cunha and Jamil Assreuy and D -M. Xu and I. P. Charles and Foo Yew Eddy Liew and Salvador Moncada},
  journal={European journal of immunology},
  year={1993},
  volume={23 6},
  pages={1385-8}
}
Murine macrophages express high levels of nitric oxide (NO) synthase and produce large amounts of NO when stimulated with interferon-gamma plus lipopolysaccharide in vitro. The expression of NO synthase peaks at 12 h after stimulation and declines rapidly to the background level by 72 h. These macrophages can be repeatedly reactivated to express similar levels of NO synthase. The reactivation is not due to newly divided cells since peritoneal macrophages which do not divide in vitro and J774… CONTINUE READING
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