Repeated implantation of skeletal myoblast in a swine model of chronic myocardial infarction.

  title={Repeated implantation of skeletal myoblast in a swine model of chronic myocardial infarction.},
  author={Ju{\'a}n Jos{\'e} Gavira and Emilio Nasarre and Gloria Abizanda and Maitane P{\'e}rez-Ilzarbe and Alba de Martino-Rodriguez and Jos{\'e} Antonio Garc{\'i}a de Jal{\'o}n and Manuel Mazo and Alfonso Mac{\'i}as and Ignacio Garc{\'i}a-Bolao and Beatriz Pelacho and Diego Mart{\'i}nez-Caro and Felipe Pr{\'o}sper},
  journal={European heart journal},
  volume={31 8},
AIMS Although transplantation of skeletal myoblast (SkM) in models of chronic myocardial infarction (MI) induces an improvement in cardiac function, the limited engraftment remains a major limitation. We analyse in a pre-clinical model whether the sequential transplantation of autologous SkM by percutaneous delivery was associated with increased cell engraftment and functional benefit. METHODS AND RESULTS Chronically infarcted Goettingen minipigs (n = 20) were divided in four groups that… CONTINUE READING
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