Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia.

@article{Bradesi2005RepeatedET,
  title={Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia.},
  author={Sylvie Bradesi and Ines Schwetz and Helena S Ennes and Christophe M. Lamy and Gordon Ohning and Michael S Fanselow and Charalabos Pothoulakis and J A Mcroberts and Emeran A. Mayer},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2005},
  volume={289 1},
  pages={G42-53}
}
Chronic stress plays an important role in the development and exacerbation of symptoms in functional gastrointestinal disorders. To better understand the mechanisms underlying this relationship, we aimed to characterize changes in visceral and somatic nociception, colonic motility, anxiety-related behavior, and mucosal immune activation in rats exposed to 10 days of chronic psychological stress. Male Wistar rats were submitted daily to either 1-h water avoidance (WA) stress or sham WA for 10… CONTINUE READING
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