Repeated exposure to benzalkonium chloride in the Ex Vivo Eye Irritation Test (EVEIT): observation of isolated corneal damage and healing.

@article{Frentz2008RepeatedET,
  title={Repeated exposure to benzalkonium chloride in the Ex Vivo Eye Irritation Test (EVEIT): observation of isolated corneal damage and healing.},
  author={M. P. Frentz and Miriam Goss and M. Reim and Norbert Franz Schrage},
  journal={Alternatives to laboratory animals : ATLA},
  year={2008},
  volume={36 1},
  pages={25-32}
}
The prediction of side-effects is a key issue in the REACH initiative on chemicals, in the production of cosmetics and in the preclinical testing of drugs. A new ex vivo test for repeated substance application is presented, that is able to identify corrosive and irritant effects on the eye by using crucial endpoints, such as cellular and morphological damage, and healing characteristics. The test is intended to replace the Draize eye test and to improve the preclinical testing of drugs and… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Occludin gene expression as an early in vitro sign for mild eye irritation assessment.

Toxicology in vitro : an international journal published in association with BIBRA • 2010
View 1 Excerpt
Highly Influenced

Storage of Porcine Cornea in an Innovative Bioreactor.

Investigative ophthalmology & visual science • 2017

Semifluorinated alkanes as a liquid drug carrier system for topical ocular drug delivery.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V • 2014

References

Publications referenced by this paper.
Showing 1-10 of 13 references

Comparison of toxicological profiles of benzalkonium chloride and polyquaternium-1: an experimental study.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics • 2006

Effect of formulation factors on in vitro transcorneal permeation of gatifloxacin from aqueous drops

M. S. Rathore
AAPS PharmSciTech • 2006

Preval idation of a new in vitro reconstituted human cornea model to assess the eye irritating potential of chemicals

F. Van Goethem, E. Adriaens, +7 authors P. Vanparys
Toxicology in Vitro • 2006

idation of a new in vitro reconstituted human cornea model to assess the eye irritating potential of chemicals

I. R. Schwab, N. T. Johnson, D. G. Harkin
Toxicology in Vitro • 2006

A collaborative evaluation of the cytotoxicity of two surfactants by using the human corneal epithelial cell line and the WST-1 test.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics • 2003

A compart ment model to calculate time dependent concentration profiles of topically applied chemical compounds in the anterior compartments of the rabbit

H. Prospisil, H. G. Holzhuetter
eye. ATLA • 2001

A compartment model to calculate time dependent concentration profiles of topically applied chemical compounds in the anterior compartments of the rabbit eye

F. Van Goethem, E. Adriaens, +7 authors P. Vanparys
ATLA • 2001

Similar Papers

Loading similar papers…