Repeated exposure of adult rats to Aroclor 1254 causes brain region-specific changes in intracellular Ca2+ buffering and protein kinase C activity in the absence of changes in tyrosine hydroxylase.

@article{Kodavanti1998RepeatedEO,
  title={Repeated exposure of adult rats to Aroclor 1254 causes brain region-specific changes in intracellular Ca2+ buffering and protein kinase C activity in the absence of changes in tyrosine hydroxylase.},
  author={Prasada Rao S. Kodavanti and Ethel C Derr-Yellin and William R. Mundy and Timothy J. Shafer and David Herr and Stanley S. Barone and Neepa Y Choksi and Robert C. Macphail and Hugh A. Tilson},
  journal={Toxicology and applied pharmacology},
  year={1998},
  volume={153 2},
  pages={186-98}
}
Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants, some of which may be neurotoxic. In vitro studies from this laboratory indicated that noncoplanar PCBs perturbed intracellular signal transduction mechanisms including Ca2+ homeostasis, receptor-mediated inositol phosphate production, and translocation of protein kinase C (PKC). In the present study, we examined the effects of PCBs in vivo by dosing adult male Long-Evans rats orally with Aroclor 1254 (0, 10, or 30 mg/kg… CONTINUE READING

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