Repeated ethanol withdrawal experience selectively alters sensitivity to different chemoconvulsant drugs in mice

@article{Becker1998RepeatedEW,
  title={Repeated ethanol withdrawal experience selectively alters sensitivity to different chemoconvulsant drugs in mice},
  author={Howard C Becker and Lynn M. Veatch and Jaime L. Diaz-Granados},
  journal={Psychopharmacology},
  year={1998},
  volume={139},
  pages={145-153}
}
 Repeated ethanol withdrawal experience has been shown to result in exacerbated seizures associated with future withdrawal episodes. This sensitization of the withdrawal response has been postulated to represent a ”kindling” phenomenon. The present study employed an established model of repeated ethanol withdrawals to examine the potential role of GABAA, and NMDA and non-NMDA glutamate receptor systems in mediating enhanced seizure activity, as assessed by sensitivity to seizures induced by… CONTINUE READING

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Repeated ethanol withdrawal experience decreases seizure threshold dosage for pentylenetetrazol ( PTZ ) and NMDA , but not kainate

JL Diaz-Granados, HC Becker, RR Reich, KG Fernandes
Alcohol Clin Exp Res • 1996

The pharmacotherapy of alcohol withdrawal

RF Anton, HC Becker
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