Repeated ethanol administration decreases prodynorphin biosynthesis in the rat hippocampus.

@article{Przewocka1992RepeatedEA,
  title={Repeated ethanol administration decreases prodynorphin biosynthesis in the rat hippocampus.},
  author={Barbara Przewłocka and Władysław Lasoń and Ryszard Przewłocki},
  journal={Neuroscience letters},
  year={1992},
  volume={134 2},
  pages={195-8}
}
The effect of single and repeated (19 days) intragastric ethanol administration on prodynorphin mRNA and alpha-neoendorphin levels in the hippocampus of the rat was studied using in situ hybridization and RIA methods, respectively. Single ethanol administration had no effect on either of these two parameters. Repeated ethanol administration decreased both immunoreactive (ir) alpha-neoendorphin (by ca. 37%) and prodynorphin mRNA (by ca. 57%) levels. Two days after the last dose of ethanol no… CONTINUE READING