Repeated electroconvulsive shock attenuates the depressive-like effects of d-amphetamine withdrawal on brain reward function in rats

@article{Barr2002RepeatedES,
  title={Repeated electroconvulsive shock attenuates the depressive-like effects of d-amphetamine withdrawal on brain reward function in rats},
  author={Alasdair M Barr and Athanasios P. Zis and Anthony G Phillips},
  journal={Psychopharmacology},
  year={2002},
  volume={159},
  pages={196-202}
}
Rationale: The withdrawal of humans from high doses of psychostimulant drugs can result in a transient syndrome which appears isomorphic to endogenous depression. One of the more prominent symptoms is a loss of hedonic capacity; in animals, the anhedonia associated with amphetamine withdrawal has been measured objectively by decrements in responding for intracranial self-stimulation (ICSS). Objective: To date, the effects of amphetamine withdrawal on ICSS responding have been reversed by… CONTINUE READING

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