Repeated dose liver and gastrointestinal tract micronucleus assays using N-methyl-N'-nitro-N-nitrosoguanidine in young adult rats.

@article{Takayanagi2015RepeatedDL,
  title={Repeated dose liver and gastrointestinal tract micronucleus assays using N-methyl-N'-nitro-N-nitrosoguanidine in young adult rats.},
  author={Tomomi Takayanagi and Yumi Wako and Kazufumi Kawasako and Hisako Hori and Wataru Fujii and Wakako Ohyama},
  journal={Mutation research. Genetic toxicology and environmental mutagenesis},
  year={2015},
  volume={780-781},
  pages={100-6}
}
N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG) is a direct-acting mutagen that induces tumors in the glandular stomach, but not in the liver or colon, of rats after oral administration. To evaluate the performance of repeated dose liver and gastrointestinal tract micronucleus (MN) assays in young adult rats, MNNG was administered by oral gavage to male CD (SD… CONTINUE READING