Repeated dose effects of lormetazepam and flurazepam upon driving performance

  title={Repeated dose effects of lormetazepam and flurazepam upon driving performance},
  author={Karel A. Brookhuis and Edmund R. Volkerts and John F. O’Hanlon},
  journal={European Journal of Clinical Pharmacology},
The residual effects of lormetazepam 1 mg and 2 mg in soft gelatine capsules on driving performance were assessed and compared to those of flurazepam 30 mg, which is also a powerful hypnotic, but possesses a far less favourable pharmacokinetic profile with a longacting sedative metabolite. Driving performance was tested 10 to 11 h and 16 to 17 h post administration, after 2 days on placebo (baseline), and 2,4 and 7 days of drug treatment (active), and after 1 and 3 days following the resumption… CONTINUE READING

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