Repeated diazepam administration influences 5-HT1A receptor binding in the rat brain.

Abstract

Repeated administration of diazepam for 14 days (5 mg/kg daily) resulted in a significant increase of 5-HT1A receptor density in the midbrain of the rat. Bmax values were increased from 239.6 to 684.9 fmol/mg. The affinity constants (KD) were also increased, from 0.97 to 3.01 nM/l. 

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Cite this paper

@article{Rump1995RepeatedDA, title={Repeated diazepam administration influences 5-HT1A receptor binding in the rat brain.}, author={S. Von Rump and I Jakowicz}, journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology}, year={1995}, volume={5 1}, pages={49-51} }