Repeated determinants within the retinal interphotoreceptor retinoid-binding protein (IRBP): immunological properties of the repeats of an immunodominant determinant.

@article{Kotake1990RepeatedDW,
  title={Repeated determinants within the retinal interphotoreceptor retinoid-binding protein (IRBP): immunological properties of the repeats of an immunodominant determinant.},
  author={Satoshi Kotake and Barbara N Wiggert and T Michael Redmond and Diane E Borst and John M. Nickerson and Hanah Margalit and J A Berzofsky and Gerald J. Chader and Igal Gery},
  journal={Cellular immunology},
  year={1990},
  volume={126 2},
  pages={
          331-42
        }
}
Interphotoreceptor retinoid-binding protein (IRBP), a glycoprotein which localizes in the retina and pineal gland, induces inflammatory changes in these organs (EAU and EAP, respectively) when injected into various mammals. We have previously identified a determinant (residues 1169-1191) in bovine IRBP which is immunodominant and highly immunogenic and immunopathogenic in Lewis rats. IRBP exhibits a fourfold repeat structure and we report here on the comparison between the active sequence 1179… CONTINUE READING