Repeated cocaine administration increases nitric oxide efflux in the rat dorsal striatum

@article{Lee2009RepeatedCA,
  title={Repeated cocaine administration increases nitric oxide efflux in the rat dorsal striatum},
  author={Dong Kun Lee and Wei Choon Alvin Koh and Y. D. Shim and Insop Shim and Eun Sang Choe},
  journal={Psychopharmacology},
  year={2009},
  volume={208},
  pages={245-256}
}
Repeated injections of cocaine alter extracellular nitric oxide (NO) efflux via interactions between dopamine and glutamate receptor-coupled signaling cascades. Putative cellular mechanisms underlying changes in NO efflux following repeated cocaine administration were investigated. Real-time detection of NO efflux using a NO biosensor was mainly performed in the rat dorsal striatum in vivo. Repeated exposure to cocaine (20 mg/kg), once a day for seven consecutive days, increased NO levels… CONTINUE READING