Repeated citalopram administration counteracts kainic acid-induced spreading of PSA-NCAM-immunoreactive cells and loss of reelin in the adult mouse hippocampus.

@article{Jaako2011RepeatedCA,
  title={Repeated citalopram administration counteracts kainic acid-induced spreading of PSA-NCAM-immunoreactive cells and loss of reelin in the adult mouse hippocampus.},
  author={K{\"u}lli Jaako and Anu Aonurm-Helm and Anti Kalda and Kaili Anier and Tamara Zharkovsky and Dmitri Shastin and Alexander Zharkovsky},
  journal={European journal of pharmacology},
  year={2011},
  volume={666 1-3},
  pages={61-71}
}
Systemic or intracerebral administration of kainic acid in rodents induces neuronal death followed by a cascade of neuroplastic changes in the hippocampus. Kainic acid-induced neuroplasticity is evidenced by alterations in hippocampal neurogenesis, dispersion of the granule cell layer and re-organisation of mossy fibres. Similar abnormalities are observed in patients with temporal lobe epilepsy and, therefore, kainic acid-induced hippocampal neuroplasticity might mimic pathological mechanisms… CONTINUE READING

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