Repeated carbon nanotube administrations in male mice cause reversible testis damage without affecting fertility

@inproceedings{Bai2010RepeatedCN,
  title={Repeated carbon nanotube administrations in male mice cause reversible testis damage without affecting fertility},
  author={Yuhong Bai and Yi Zhang and Jing Zhang and Qingxin Mu and Weidong Zhang and Elizabeth R. Butch and Scott E Snyder and Bing Yan},
  booktitle={Nature nanotechnology},
  year={2010}
}
Soluble carbon nanotubes show promise as materials for in vivo delivery and imaging applications. Several reports have described the in vivo toxicity of carbon nanotubes, but their effects on male reproduction have not been examined. Here, we show that repeated intravenous injections of water-soluble multiwalled carbon nanotubes into male mice can cause reversible testis damage without affecting fertility. Nanotubes accumulated in the testes, generated oxidative stress and decreased the… CONTINUE READING
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